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The a16z Show

Healthcare Never Built Middleware, So It Can Leap Straight to AI-Native

US healthcare spends the smallest share of revenue on technology of any industry and never laid down a SaaS middle layer, so there's no sunk cost to rip out — this is its first organic adoption wave, with doctors adopting technology on their own.

Healthcare AIDigital HealthStartup OpportunityPayment ModelsAI-Native

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The densest 27 minutes are the middle and back half: why healthcare can leapfrog, the AI native + AI proof framework, and the call on the ‘N of one’ data flywheel. The first half is personal history and can be fast-forwarded.

The argument · tap a timestamp to hear it

11:20

Before LLMs, healthcare's scarcity came from years of training

Julie's causal chain: healthcare is esoteric because it depends heavily on scarce training — to become a specialist provider you need at least seven years of schooling plus training. Before LLMs brought abundant intelligence, the bar to build technology approaching that level of expertise was extremely high. So AI isn't just another efficiency tool; it's the first time ‘replicating expert judgment’ becomes economically feasible. She also points to the push from the payment side: the third-party payer system means consumers don't feel the pain of each dollar, so the system accumulated far more bloat than free-market dynamics would allow, and both government and payers are now squeezing that cost.

— Julie Yoo
11:20

Deductibles turned consumers into real payers

Employers used to cover most of the premium, so employees felt no financial pain. Then cost shifting began, introducing deductibles — for example, insurance doesn't kick in below $1,000, so you pay it all yourself. Julie says this is exactly what made consumers realize for the first time ‘this is what I'm paying so much for, and it's terrible service’, so they started voting with their feet and their wallets. The number she gives: there are now companies where you pay $10 a month out of pocket and get excellent service, and the same money buys something 1,000 times worse in the traditional system. That's the direct source of the demand-side adoption wave.

— Julie Yoo
13:22

Healthcare never built middleware, so it can skip a grade

Julie says healthcare is the industry with ‘the lowest tech spend as a share of revenue’. Other industries spent decades and tens of billions laying down a workflow SaaS middle layer, so when AI arrives they have to rip and replace and retrain an entire generation of employees. Healthcare only has EHR as its one ERP layer, with everything else propped up by human labor, so it has no sunk-cost bias and can jump straight to agentic forms. She calls this the leapfrog dynamic — past technology adoption in healthcare was unnatural (paying doctors to use it, the pandemic forcing telehealth into existence), and this is the first organic adoption: doctors use AI scribes because it genuinely helps and changes the nature of their work.

— Julie Yoo
18:33

AI solved ‘knowing’, not ‘then what’

Julie breaks AI's role in healthcare into three stages: the first is lowering the barrier to accessing intelligence, which general-purpose tools have already solved; the second is that once you have a judgment you need to verify it, run clinical-grade tests, prescribe or operate, and have someone actually show up; the third is longitudinal — staying with you until the problem is solved and until the next problem appears. She says today's medical AI is highly transactional, and the real opportunity is in the second and third stages, the ‘last mile’ that health tech builders have to chew through. Her example is portfolio company Council Health: an AI-native doctor's office with 24×7 asynchronous chat, where the chat room has licensed MDs who can prescribe, refer, and diagnose.

— Julie Yoo
20:37

Seven years ago, raising consumer health got you thrown out of the room

Julie says seven years ago, mentioning consumer health in front of any investor got you kicked out of the room, because there was no viable business model, consumers had no agency, and the payment model didn't exist. That's changed: the fastest-growing companies in health tech are cash pay — direct out-of-pocket, low price disruption. She thinks the biggest lever is cost structure, and AI makes delivering a medically credible service about 100 times cheaper than before. The product design order has flipped too: it used to be designed for insurers and doctors first with the consumer bolted on afterward, and now the consumer is at the top of the stack. She wrote an article about this called consumers are the new payer.

— Julie Yoo
21:40

The best companies have to be AI native and AI proof at once

Julie's article last week proposed AI native and AI proof: LLMs can answer questions you used to have to wait six months to see a specialist to ask, but the rest — making house calls for people who can't get to a hospital, drawing blood and actually diagnosing what you have, doing the things only regulated entities can legally do in the US — AI itself can't solve. So she points the opportunity at full-stack challenger companies: they look like a retailer or a service provider on the outside, are highly AI native on the inside, and therefore have surface area and a disruptive cost structure that were historically unattainable, with high margins that can fund further innovation. Hardware and robotics are in scope too; she thinks robots have already found product-market fit in high-acuity healthcare settings.

— Julie Yoo
23:46

The healthcare payment system isn't broken, it runs as designed

Faced with complaints about how bad healthcare is, Julie's answer is: it's actually exactly as planned — if you study how incentives are aligned under the payment system, today's outcome is its inevitable product. So the most ambitious companies are asking: can we blow up the existing payment model and build a new one from scratch, essentially building a mini healthcare system inside one company. She names Devoted Health as doing this, and says it's possible now because the cost of entry to build a company has dropped (the infrastructure already exists), AI can do more, and appetite on both the consumer and traditional-ecosystem sides is unprecedented.

— Julie Yoo
24:52

The dataset to train medical-grade AI doesn't actually exist

Julie's judgment: we don't even have the dataset needed to train medical-grade AI. Because today it depends heavily on EHR data, and EHR is sporadic — you see a traditional doctor at most once a year over a lifetime, so the full narrative arc of you as a patient is almost entirely absent from every existing dataset. Her inference is N of one health: lots of companies will run hyper-personalized experiments on just you, and those experiments generate new data tracks that then drive the next generation of models. She also gives a ten-year prediction: every one of us will have a lifelong AI doctor in our pocket.

— Julie Yoo

In their own words · checked verbatim

Healthcare for better, for worse, did not spend that amount of money, right? So we only had really like the ERP layer with EHRs, and then labor, like we were just throwing bodies at every problem.

Julie Yoo13:22

we have less of a sunk cost bias as an industry to say, okay, this new technology paradigm has come along, and we can just leap right to it.

Julie Yoo14:25

This is currently is the only like the first real organic adoption wave that we've seen in health tech where doctors are just using AI scribes because they freaking work and they're so good and they really change the nature of their job for the positive.

Julie Yoo15:29

I'm like, it's actually designing exactly as planned. Like if you actually study the innards of how incentives are aligned based on the payment system that exists in healthcare, it results in exactly what we experience today.

Julie Yoo23:46

I would argue that we actually don't even have the datasets necessary to truly train like a medical grade AI because we rely heavily today on electronic health record data, which is really sporadic, right?

Julie Yoo24:52

So I think a lot of companies will start doing these kind of N of one experiments that generate the new data rails that then drive the next generation of models that are built in our space.

Julie Yoo25:52

Figures

Julie Yoo's years in healthcareabout 18 years1:00
Years she worked as a software engineer7 years1:00
Time for full EHR deployment across US doctorsabout 5-7 years2:03
Minimum schooling plus training to become a specialist providerat least 7 years11:20
Deductible example: out-of-pocket ceiling before insurance kicks inyou pay out of pocket below $1,00011:20
Monthly fee for consumer subscription healthcare$10/month12:22
Multiple by which AI cuts the cost of delivering a medically credible serviceabout 100x20:37
Gap in service bought for the same spend under the traditional system1,000x12:22
Out-of-pocket cost of going to the emergency room$2,00016:31

Glossary

leapfrog dynamic
Never having laid down the previous generation of middleware, so you can skip it and adopt the new technology paradigm directly.
AI native and AI proof
Julie's framework: use AI to restructure the cost base while also doing the offline and compliance work AI itself can't do.
N of one
Running hyper-personalized analysis on a single individual, generating new data tracks that feed back into models.
AI scribes
Tools that automatically record doctor-patient conversations and generate medical notes; the entry scenario for doctors adopting AI on their own.
third-party payer system
Medical costs are paid mainly by insurers or employers rather than patients, producing a lack of price sensitivity and system bloat.

How to listen

Who it's for

Founders building healthcare AI or digital health, investors looking at the healthcare sector, and engineers who want to know which vertical AI cracks the business model first.

Skip

The personal history and industry-history setup from 0:00-8:16; you can start listening at 8:16.