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From First Principles

First-principles digs into quantum computing, AI and science, with firsthand papers and hardware detail; claims refutable.

Deep reads here3 / 64 episodes
Cadence~1 every 5.9 days
Latest2026-10-16
TopicsScience & Medicine
PriorityT3
2:07:22
From First Principles 0929

Shatter tumors instead of burning them—the immune system recognizes the debris

Sound waves shatter tumors rather than carbonizing them, leaving cellular fragments with intact tumor antigens that let the immune system learn to recognize and suppress distant metastases.

8 Points 6 Quotes Medical devicesPrecision medicine
4:09:02
From First Principles 0924

OpenAI's 165-Page Proof That Viscosity Loses to Nonlinearity

What fell in the Navier-Stokes millennium problem is the version with external forcing: energy goes to zero while velocity blows up to infinity. And OpenAI's starting point was hearing that Anthropic might get there first.

9 Points 8 Quotes MathematicsFluid Dynamics
3:46:20
From First Principles 0831

The quantum endgame isn't whose qubits are cleaner, it's who can mass-produce them on a phone-chip line

The endgame of quantum computing isn't whose qubits are cleaner, it's who can mass-produce them on existing semiconductor lines; silicon spin qubits reuse TSMC's lithography, while trapped ions are stuck at a hundred thousand laser beams and superconductors at warehouse-scale refrigerators.

8 Points 7 Quotes Quantum computingSilicon spin