From Our Neurons to Yours
Frontier brain science interviews from Stanford's neuroscience institute; solid mechanism work, claims clearly refutable.
52:27Sugar on the cell surface isn't frosting — it's the brain's moat
The mucins on the brain's vascular endothelium are like a redwood forest; with age the leaves fall off and the blood-brain barrier gets leaky. Restore the enzyme with gene therapy and mice remember better.
49:54After GLP-1: Injections Are No Longer a Barrier, Peptide Drugs Enter a New Era
Injectable drugs are no longer a barrier; peptide drugs are expanding from weight loss to exercise mimetics, neural regulation, and beyond. Scientists caution: outside GLP, data are still sparse, and approval cycles could take up to 20 years.
46:21TMS for depression only works half the time: the bottleneck is we don't know how it changes the brain
TMS is in the clinic but still a black box; unclear mechanisms keep efficacy at 50%. Using intracranial electrodes in epilepsy patients to get ground truth from neurons, the next step is to refine EEG biomarkers, turning treatment from parameter guessing into closed-loop optimization.