The Peter Attia Drive
Long-form longevity medicine: lipids, metabolism and sleep broken down to markers, doses and strength of evidence
Deep reads here2 / 459 episodes
Cadence~1 every 7.0 days
Latest2026-10-05
TopicsScience & Medicine
PriorityT3
2:26:26The Peter Attia Drive
0928
A muscle antibody Novartis abandoned matched weight-loss surgery's fat loss when combined with GLP-1
This muscle-building antibody, abandoned by Novartis, achieved 45.7% fat loss and 22%-23% weight reduction when combined with semaglutide for 72 weeks—the first drug therapy to match weight-loss surgery's fat-loss results.
8 Points
8 Quotes
Drug developmentClinical trials
1:59:22The Peter Attia Drive
0914
Push LDL below 80 and you may never get heart disease
The 8-gram rule: LDL 200 for 40 years, 100 for 80 years, 80 for 100 years — all add up to 8 grams of cholesterol. Lowering LDL works best before a heart attack; after heart failure sets in, it no longer helps.
12 Points
11 Quotes
CardiovascularAlzheimer's