反疫苗不是新現象：珍納原著裡就寫滿了罵他的話

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There's no reason to do that. Well, Trump says that if you do that, the rates of autism are going to go down. And there's no evidence for that, of course, because vaccines do not cause autism.

沒有理由這樣做。特朗普說如果這樣做，自閉症發病率就會下降。當然這沒有證據，因為疫苗不會導致自閉症。

Vincent Racaniello8:32

Vaccinations are part of child care. We know that they're really important. And so pushing back against well-studied and recommended vaccines is essentially child abuse.

疫苗接種是兒童照護的一部分。我們知道它們非常重要。因此反對經過充分研究和推薦的疫苗，本質上就是虐待兒童。

Vincent Racaniello12:50

only between two and 50% of the RNA polymerase in the cell is actively associated with sigma A at any given time.

在任何時刻，細胞中只有2%到50%的RNA聚合酶與σA因子活躍結合。

Jolene Ramsey47:22

what renders cowpox virus so extremely singular is that the person who has been thus affected is forever secure from infection of the smallpox. And the marginal note says, what humbug.

珍納寫道：「牛痘病毒之所以極其獨特，在於受過感染的人將永遠免受天花感染。」而頁邊批註寫著：「胡說八道。」

Rich1:42:46

anti-vax is as old as vax. It comes from the very beginning.

反疫苗與疫苗本身一樣古老，它從一開始就存在。

Rich1:47:51

this is deranged nonsense expressed in the words of someone whose cerebral cortex is shedding vocabulary by the day. Vaccination thing, really? A brief reminder, this man not only imagines he is making medical policy, but he also has the nuclear launch codes. And that part is unfortunately no delusion.

這是精神錯亂的胡言亂語，出自一個大腦皮層每天都在流失詞彙的人之口。「疫苗東西」，真的嗎？提醒一下，這個人不僅幻想自己在制定醫療政策，他還掌握著核發射密碼。而這一部分不幸並非妄想。

Vincent1:58:56

數字與實體

術語

liquid-liquid phase separation (LLPS)液-液相分離

細胞內分子聚集形成無膜細胞器的過程，與轉錄調控相關。

intrinsically disordered region (IDR)內在無序區

蛋白質中無固定三維結構但功能重要的區域，常參與相分離。

biomolecular condensate生物分子凝聚體

通過相分離形成的無膜細胞器，濃縮特定蛋白和核酸。

RNA polymerase holoenzymeRNA聚合酶全酶

核心酶與σ因子結合後的形式，能識別啟動子起始轉錄。

vaccinia virus factory疫苗病毒工廠

病毒在細胞內複製組裝的區域，由病毒蛋白誘導形成。

synonymous substitution rate同義替換率

不改變氨基酸的核苷酸突變速率，反映進化時間。

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