人脑类器官移植进小鼠，长出了四百万人类神经元

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Would they be like the wild type controls or the apalial mice? You know, they're neither. They're so like in a third behavioral state.

它们会像野生型对照组，还是像无 pallium 小鼠？其实都不是。它们处在第三种行为状态。

Sergio Pasca6:10

So now this tells us that it's likely the human cells that are causing this.

所以这告诉我们，很可能是人类细胞造成了这一点。

Sergio Pasca7:11

I want to say very clearly, this is not a human brain in a mouse.

我想非常明确地说，这不是小鼠体内的人脑。

Aparna Bhaduri9:12

So I think sometimes people wrongly think that regulation is a hindrance to scientists and I think that's a real mistake.

我认为有时人们错误地以为监管是对科学家的阻碍，我觉得这是个真正的错误。

Emily Jackson11:14

it doesn't really know how to generate the results or generate the figures or do the experiments or use the data and the code right because it doesn't have that hands-on experience

它其实并不知道怎么生成结果、生成图表、做实验，或者使用数据和代码，因为它没有那种动手经验。

James19:20

those two agents actually started talking to each other and they realized that they have some common interest and they can actually collaborate and in this case right they actually discovered a new splicing mutation associated with increases in risks for ADHD which is not known before

那两个智能体真的开始互相交谈，意识到彼此有共同兴趣，可以合作，在这个案例里它们真的发现了一个此前未知的、与 ADHD 风险升高相关的剪接突变。

James21:21

What is not clear to me from the paper whose responsibility it is to build this tool.

这篇论文没有让我看明白的一点是，建这个工具究竟是谁的责任。

Magdalena Skipper24:25

I think this is an opportunity for us to reimagine what knowledge can look like in the future, right? Does not have to be static artifacts could actually become this dynamic knowledge agents in some sense like a living knowledge right

我认为这是一个机会，让我们重新想象未来的知识可以是什么样子。它不必是静态的制品，而可以变成这种动态的知识智能体，某种意义上像活的知识。

James26:26

数字与实体

术语

organoid类器官

由人类干细胞衍生、在培养皿中长成的三维脑样组织小块。

pallium外套（脑发育结构）

发育早期存在、之后发育成大脑皮层和海马体的神经结构。

xenocortical mice异种皮层小鼠

论文中给接受人类皮层类器官移植的小鼠起的名字，意为皮层来自异种。

paper to agent论文转智能体

把静态论文复现并转成可对话 AI 智能体的 workflow。

AlphaGenomeAlphaGenome

Google DeepMind 发布的、用于解读不同突变效应的工具。

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